Cytokine-Chemokine Networks in Experimental Mycobacterial and Schistosomal Lung Granuloma Formation
نویسندگان
چکیده
Type-1 and type-2 lung granulomas respectively elicited by bead immobilized Mycobacteria bovis (PPD 1) and Schistosoma mansoni egg (SEA) Ags display different patterns chemokine expression. This study tested the hypothesis that chemokine expression patterns were related to upstream cytokine signaling. Using quantitative transcript analysis we defined expression profiles for 16 chemokines and then examined the in vivo effects of neutralizing antibodies against interferon-gamma (IFNγ), interleukin-4 (IL-4), IL-10, IL-12, and IL-13. either Th1-or Th2-related cytokines although some of these showed biased expression. IFNγ and IL-4 enhanced the greatest complement of transcripts and their neutralization had the greatest anti-inflammatory effect on type-1 and type-2 granulomas, respectively. Th1/Th2 cross-regulation was evident since endogenous Th2 cytokines inhibited type-1, whereas Th1 cytokines inhibited type-2 biased chemokines. These findings reveal a complex cytokine-chemokine regulatory network that dictates profiles of local chemokine expression during T cell-mediated granuloma formation.
منابع مشابه
Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation.
Type-1 and type-2 lung granulomas, respectively, elicited by bead immobilized Mycobacteria bovis and Schistosoma mansoni egg antigens (Ags) display different patterns of chemokine expression. This study tested the hypothesis that chemokine expression patterns were related to upstream cytokine signaling. Using quantitative transcript analysis, we defined expression profiles for 16 chemokines and...
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